Freshman Organic Chemistry

Course Description

This is the first semester in a two-semester introductory course focused on current theories of structure and mechanism in organic chemistry, their historical development, and their basis in experimental observation. The course is open to freshmen with excellent preparation in chemistry and physics, and it aims to develop both taste for original science and intellectual skills necessary for creative research.

Course Structure: This Yale College course, taught on campus three times per week for 50 minutes, was recorded for Open Yale Courses in Fall 2008.

Original Course Title: CHEM 125: Freshman Organic Chemistry

Freshman Organic Chemistry

J. Michael McBride is the Richard M. Colgate Professor of Chemistry at Yale University. After undergraduate work at the College of Wooster and Harvard College Professor McBride earned a Ph.D. in physical organic chemistry at Harvard University. He joined the Yale Chemistry faculty in 1966, where he studies crystal growth and reactions in organic solids. His awards include the Prelog Medal, the Nobel Laureate Signature Award in Graduate Education, and the Catalyst Award of the Chemical Manufacturers Association for undergraduate education.
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Video Lectures & Study Materials

# Lecture Play Lecture
1 How Do You Know? Play Video
2 Force Laws, Lewis Structures and Resonance Play Video
3 Double Minima, Earnshaw's Theorem, and Plum-Puddings Play Video
4 Coping with Smallness and Scanning Probe Microscopy Play Video
5 X-Ray Diffraction Play Video
6 Seeing Bonds by Electron Difference Density Play Video
7 Quantum Mechanical Kinetic Energy Play Video
8 One-Dimensional Wave Functions Play Video
9 Chladni Figures and One-Electron Atoms Play Video
10 Reality and the Orbital Approximation Play Video
11 Orbital Correction and Plum-Pudding Molecules Play Video
12 Overlap and Atom-Pair Bonds Play Video
13 Overlap and Energy-Match Play Video
14 Checking Hybridization Theory with XH3 Play Video
15 Chemical Reactivity: SOMO, HOMO, and LUMO Play Video
16 Recognizing Functional Groups Play Video
17 Reaction Analogies and Carbonyl Reactivity Play Video
18 Amide, Carboxylic Acid and Alkyl Lithium Play Video
19 Oxygen and the Chemical Revolution (Beginning to 1789) Play Video
20 Rise of the Atomic Theory (1790-1805) Play Video
21 Berzelius to Liebig and Wohler (1805-1832) Play Video
22 Radical and Type Theories (1832-1850) Play Video
23 Valence Theory and Constitutional Structure (1858) Play Video
24 Determining Chemical Structure by Isomer Counting (1869) Play Video
25 Models in 3D Space (1869-1877); Optical Isomers Play Video
26 Van't Hoff's Tetrahedral Carbon and Chirality Play Video
27 Communicating Molecular Structure in Diagrams and Words Play Video
28 Stereochemical Nomenclature; Racemization and Resolution Play Video
29 Preparing Single Enantiomers and the Mechanism of Optical Rotation Play Video
30 Esomeprazole as an Example of Drug Testing and Usage Play Video
31 Preparing Single Enantiomers and Conformational Energy Play Video
32 Stereotopicity and Baeyer Strain Theory Play Video
33 Conformational Energy and Molecular Mechanics Play Video
34 Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes Play Video
35 Understanding Molecular Structure and Energy through Standard Bonds Play Video
36 Bond Energies, the Boltzmann Factor and Entropy Play Video
37 Potential Energy Surfaces, Transition State Theory and Reaction Mechanism Play Video


Displaying 3 comments: wrote 10 years ago.
Love the name of this band, but they actually are a real
tiger, no phoniness here. Nicely done.

partha1kundu wrote 13 years ago.
Great!!!!! Please upload the next semester organic chemistry

partha wrote 13 years ago.
Great course!!!!!!!!! Please upload the second semester
course which will be very helpful...

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