Systems Biology

Course Description

This course presented by Prof. Jeff Gore provides an introduction to cellular and population-level systems biology with an emphasis on synthetic biology, modeling of genetic networks, cell-cell interactions, and evolutionary dynamics. Cellular systems include genetic switches and oscillators, network motifs, genetic network evolution, and cellular decision-making. Population-level systems include models of pattern formation, cell-cell communication, and evolutionary systems biology.

Systems Biology
A neutrophil (a type of white blood cell, shown in blue-gray) interacting with Klebsiella pneumoniae bacteria (shown in pink). This is one example of the types of functions that Systems Biology seeks to understand and describe. Watch Lecture 1 to see a video of a neutrophil chasing and engulfing a bacterium. (Image by NIAID, CC-BY.)
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Video Lectures & Study Materials

Visit the official course website for more study materials:

# Lecture Play Lecture
1 Introduction to the class and overview of topics Play Video
2 Input function, Michaelis-Menten kinetics, and cooperativity Play Video
3 Autoregulation, feedback and bistability Play Video
4 Synthetic biology and stability analysis in the toggle switch Play Video
5 Oscillatory genetic networks Play Video
6 Graph properties of transcription networks Play Video
7 Feed-forward loop network motif Play Video
8 Introduction to stochastic gene expression Play Video
9 Causes and consequences of stochastic gene expression Play Video
10 Stochastic modeling Play Video
11 Life at low Reynold’s number Play Video
12 Robustness and bacterial chemotaxis Play Video
13 Robustness in development and pattern formation Play Video
14 Microbial evolution experiments and optimal gene circuit design Play Video
15 Evolution in finite populations Play Video
16 Clonal interference and the distribution of beneficial mutations Play Video
17 Fitness landscapes and sequence spaces Play Video
18 Evolutionary games Play Video
19 Survival in fluctuating environments Play Video
20 Parasites, the evolution of virulence and sex Play Video
21 Interspecies interactions Play Video
22 Ecosystem stability, critical transitions, and biodiversity Play Video
23 Dynamics of populations in space Play Video
24 The neutral theory of ecology Play Video


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