Useful Genetics

Course Description

This college-level course gives students a thorough understanding of gene function, and enables them to apply this understanding to real-world issues, both personal and societal.

Copyright Information

This content is provided under a Creative Commons License: https://creativecommons.org/licenses/by-sa/3.0/

Course Introduction Video
Useful Genetics
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Video Lectures & Study Materials

Visit the official course website for more study materials: https://www.coursera.org/course/usefulgenetics

# Lecture Play Lecture
I. How Different Are We?
1 Overview of Module 1 (2:45) Play Video
2 How different are we? (11:25) Play Video
3 Properties of DNA (17:21) Play Video
4 Properties of genes (19:56) Play Video
5 Why molecular biology is confusing (9:52) Play Video
6 Properties of chromosomes (14:55) Play Video
7 Life cycles and ploidy (15:30) Play Video
8 Comparing DNA sequences (18:25) Play Video
9 Genetic and evolutionary relationships of human populations (12:55) Play Video
II. Mutations
10 Overview of Module 2 (3:58) Play Video
11 Fidelity of DNA replication (21:07) Play Video
12 Why most mutations are harmless (21:32) Play Video
13 Types of mutations and their consequences (25:01) Play Video
14 Germline and Somatic Mutations (19:29) Play Video
15 Mutagens (what should we worry about) (18:55) Play Video
16 Mutations, selection and evolvability (10:34) Play Video
17 Origins and evolution of new genes and gene families (16:18) Play Video
18 Comparing DNA sequences reveals evolutionary history (17:16) Play Video
III. DNA Differences and Gene Functions
19 Overview of Module 3 (6:42) Play Video
20 Protein basics (16:51) Play Video
21 Catalytic proteins (enzymes) (16:22) Play Video
22 Structural, transport and carrier proteins (15:50) Play Video
23 Regulatory proteins and RNAs (20:29) Play Video
24 Homozygous phenotypes (16:56) Play Video
25 Diploids: Heterozygous phenotypes (8:52) Play Video
26 All about dominance (17:31) Play Video
27 How genes are named (19:30) Play Video
28 Gene interaction in biochemical pathways (14:12) Play Video
29 Regulatory interactions (12:45) Play Video
30 How somatic mutations cause cancer (17:55) Play Video
31 Frameworks for predicting the phenotypic effects of mutation (2:08) Play Video
IV. Natural Genetic Variation
32 Overview of Module 4 (6:18) Play Video
33 Sex chromosomes and sex determination (10:07) Play Video
34 Expression of X‐linked genes in females (15:22) Play Video
35 Expression of X‐linked genes in males (12:29) Play Video
36 Can natural genetic variation explain natural phenotypic variation? (19:35) Play Video
37 Most natural variation has very small effects (24:31) Play Video
38 Many natural genetic variants affect multiple traits (21:29) Play Video
39 Effects of natural genetic variation depend on the environment (11:45) Play Video
40 Effects of natural genetic variation depend on chance (13:41) Play Video
41 How natural genetic variation affects the risk of cancer (26:01) Play Video
42 Integrating new understanding into old concepts (16:50) Play Video
V. Personal Genomics
43 Overview of Module 5 (4:38) Play Video
44 DNA fingerprinting (21:55) Play Video
45 Analyzing a single gene or gene 'panel' (14:30) Play Video
46 SNP-typing the genome, Part 1 (22:54) Play Video
47 SNP-typing the genome, Part 2 (26:10) Play Video
48 SNP-typing services (15:31) Play Video
49 Exome sequencing (21:26) Play Video
50 Haplotypes (26:31) Play Video
51 Ancestry (29:54) Play Video
52 Ethical and social issues surrounding personal genomics (12:00) Play Video
53 Not-so-personal genomics (18:50) Play Video
VI. The Mechanics of Inheritance
54 Overview of Module 6 (5:23) Play Video
55 Mitosis (20:20) Play Video
56 Sexual life cycles (12:04) Play Video
57 Meiosis, the basics (16:11) Play Video
58 Following genotypes through meiosis, part 1 (21:21) Play Video
59 More about meiosis: homolog pairing and crossing-over (20:52) Play Video
60 Following genotypes through meiosis (this time with crossovers) (16:25) Play Video
61 Mating (14:41) Play Video
62 Following alleles through generations (23:12) Play Video
63 Relatedness (14:17) Play Video
64 Sex chromosomes in meiosis (11:45) Play Video
VII. Genetic Analysis
65 Overview of Module 7 (5:59) Play Video
66 Genetic analysis began with Mendel (9:58) Play Video
67 Mendels findings and what we now know (10:35) Play Video
68 How to do genetic analysis (30:45) Play Video
69 Mendel's genetic analysis (20:58) Play Video
70 Detecting sex-linkage, predicting outcomes (19:48) Play Video
71 Using crosses to investigate locations of autosomal genes (21:32) Play Video
72 Using pedigrees to investigate family inheritance (18:45) Play Video
73 Using crosses to investigate gene function (20:02) Play Video
74 Genetic analysis: numbers matter (25:04) Play Video
VIII. All about Breeding and Inbreeding
75 Overview of Module 8 (3:04) Play Video
76 Heritability (27:58) Play Video
77 GWAS redux (23:32) Play Video
78 Inbreeding (20:52) Play Video
79 Inbreeding in livestock and pets (18:40) Play Video
80 Inbreeding and genetic variation in evolution and conservation (7:33) Play Video
81 Hybrids (31:26) Play Video
82 Plant Breeding & Transgenics (25:44) Play Video
IX. Chromosomal Changes
83 Overview of Module 9 (2:30) Play Video
84 Polyploidy (31:59) Play Video
85 Aneuploidy (19:40) Play Video
86 Aneuploidy for sex chromosomes (20:26) Play Video
87 Chromosomes rearrangements (23:56) Play Video
88 Consequences of chromosome rearrangements (24:33) Play Video
89 Small changes (structural variation) (22:17) Play Video
90 Junk and selfish DNA (23:31) Play Video
91 Genome evolution (23:24) Play Video
X. Selected Advanced Topics
92 Overview of Module 10 (3:02) Play Video
93 Origin of Life (15:28) Play Video
94 Mitochondrial genetics (30:52) Play Video
95 Epigenetics (37:50) Play Video
96 Mosaics and chimeras (21:36) Play Video
97 Fetal DNA (19:37) Play Video
98 Genetics of aging (29:19) Play Video

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