Professor Saltzman starts the lecture with an introduction to pharmacokinetics and pharmacodynamics. Professor Saltzman talks about the concept of dose-response. He introduces different routes of drug administration and how they affect drug distribution and bioavailability (i.e., intravenous, oral, and sublingual routes). First-pass drug metabolism by the liver is also identified as an important source of drug degradation. Finally, modeling the body as a well-stirred vessel, Professor Saltzman explains the first-order rate equation: C = (M0/V)*e-kt, that can be used calculate the amount of drug in the body (M) as a function of time (t) and a rate constant (k); and the equation for drug half-life: t = ln(2/k).

1. What Is Biomedical Engineering?
2. What Is Biomedical Engineering? (cont.)
3. Genetic Engineering
4. Genetic Engineering (cont.)
5. Cell Culture Engineering
6. Cell Culture Engineering (cont.)
7. Cell Communication and Immunology
8. Cell Communication and Immunology (cont.)
9. Biomolecular Engineering: Engineering of Immunity
10. Biomolecular Engineering: Engineering of Immunity (cont.)
11. Biomolecular Engineering: General Concepts
12. Biomolecular Engineering: General Concepts (cont.)
13. Cardiovascular Physiology
14. Cardiovascular Physiology (cont.)
15. Cardiovascular Physiology (cont.)
16. Renal Physiology
17. Renal Physiology (cont.)
18. Biomechanics and Orthopedics
19. Biomechanics and Orthopedics (cont.)
20. Bioimaging
21. Bioimaging (cont.)
22. Tissue Engineering
23. Tissue Engineering (cont.)
24. Biomedical Engineers and Cancer
25. Biomedical Engineers and Artificial Organs

The course covers basic concepts of biomedical engineering and their connection with the spectrum of human activity. It serves as an introduction to the fundamental science and engineering on which biomedical engineering is based. Case studies of drugs and medical products illustrate the product development-product testing cycle, patent protection, and FDA approval. It is designed for science and non-science majors.