Copyright Information: Penner, Reginald Thermodynamics and Chemical Dynamics 131C (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/chem_131c_thermodynamics_and_chem... [January 28, 2015]. License: Creative Commons Attribution-ShareAlike 3.0 United States License. (http://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US).
Slide Information 00:06- Enzymes (Second & Final Attempt) 00:45- Announcements 02:42- Chem 1 Students... 04:47- Today: Enzyme Kinetics, Enzyme Inhibition 5:00- How Enzymes Catalyze Reactions 07:27- Equations Specific to Enzyme Catalysis, Rate of Reaction 12:36- The Michaelis-Menten Equation 13:04- Simplifying the Rate of Reaction 15:20- Making the Michaelis-Menten Equation Useful 15:46- What's Happening if K2 is big? 16:56- If K2 is Big, if [S] is Big 17:56- And if [S] is Big, Then... 19:49- IF [S] is Small 20:27- Plot of Reaction Rate vs. Concentration of S 23:57- K2=Kcat=Turnover Number 24:30- Ratio Between V and Vmax 25:34- Basis for the Lineweaver-Burk Plot 27:15- The Lineweaver-Burk Plot 28:30- Problem From Last Year's Final Exam 31:28- What Could Possibly Happen to Mess This Up? 32:56- Classifying Inhibitors Based Upon Their Effect on the Lineweaver-Burk Plot 34:46- Three Flavors of Enzyme Inhibition: Competitive Inhibition 35:10- Out Competing a Competitive Inhibitor: Plot 37:10- What Influence Does Vmax Have on the Lineweaver-Burk Plot? 37:57- Noncompetitive Inhibition 39:28- Uncompetitive Inhibition 40:26- Derive the Math For the Plots 43:13- No Inhibitor/Inhibitor Equations 44:07- Table of Inhibition 45:18- The Classical Case of Competitive Inhibition: Malonate and SD 46:09- Succinate 46:15- Fumarate 46:36- Competitive Inhibitors Generally Resemble the Substrate of the Protein to which They Bind
In Chemistry 131C, students will study how to calculate macroscopic chemical properties of systems. This course will build on the microscopic understanding (Chemical Physics) to reinforce and expand your understanding of the basic thermo-chemistry concepts from General Chemistry (Physical Chemistry.) We then go on to study how chemical reaction rates are measured and calculated from molecular properties. Topics covered include: Energy, entropy, and the thermodynamic potentials; Chemical equilibrium; and Chemical kinetics.
Chemistry Dept. | Physical Sciences Sch. | University of California, Irvine