Intrinsic and Innate Defenses 
Intrinsic and Innate Defenses
by Columbia University / Vincent Racaniello
Video Lecture 14 of 26
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Date Added: July 26, 2012

Lecture Description

In this and the next lecture, we discuss the myriad defenses on and in a animal host that are engaged upon encounters with viruses. If a virus gets past the chemical and physical defenses of the host, next in its way stands intrinsic defenses (always present in the cell), and then innate defenses (which must be induced by infection). Both are highly effective antiviral systems, but are antagonized by many different viral proteins - and this is one reason why viruses are successful at being maintained in populations.

Course Index

Course Description

In this course, Prof. Vincent Racaniello gives 26 video lectures on Virology. The basic thesis of the course is that all viruses adopt a common strategy. The strategy is simple:

1. Viral genomes are contained in metastable particles.
2. Genomes encode gene products that promote an infectious cycle (mechanisms for genomes to enter cells, replicate, and exit in particles).
3. Infection patterns range from benign to lethal; infections can overcome or co-exist with host defenses.

Despite the apparent simplicity, the tactics evolved by particular virus families to survive and prosper are remarkable. This rich set of solutions to common problems in host/parasite interactions provides significant insight and powerful research tools. Virology has enabled a more detailed understanding of the structure and function of molecules, cells and organisms and has provided fundamental understanding of disease and virus evolution.

The course will emphasize the common reactions that must be completed by all viruses for successful reproduction within a host cell and survival and spread within a host population. The molecular basis of alternative reproductive cycles, the interactions of viruses with host organisms, and how these lead to disease are presented with examples drawn from a set of representative animal and human viruses, although selected bacterial viruses will be discussed.

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