Phenol Synthesis
Hydroxylations of Haloarenes, Williamson synthesis, phenols and esters, electrophilic aromatic substitution, Kolbe-Schmitt reaction, Allylxyphenols and the Claisen rearrangement, Cope rearrangement, Benzenediols-Benzoquinones, Arenamines, Retrosynthetic connection of phenols to Arenes

1. Lecture 1: Delocalized Pi Systems: 2-Propenyl
2. Lecture 2: Delocalized Pi Systems: Butadiene, Extended Conjugation, and the Diels-Alder Cycloaddition
3. Lecture 3: Electrocyclic Reactions
4. Lecture 4: Benzene and Aromaticity, Huyckel Rule
5. Lecture 5: Electrophilic Aromatic Substitution, Activators and Deactivators
6. Lecture 6: Directing Effects in Electrophilic Aromatic Substitution and Synthetic Applications
7. Lecture 7: Electrophilic Aromatic Substitution of Naphthalene; Aldehydes and Ketones: Names and Old Chemistry
8. Lecture 8: Aldehydes and Ketones: Reversible Addition Reactions
9. Lecture 10: Wolff-Kishner Reduction, Wittig Reaction, Baeyer-Villiger Oxidation, Enols, Enolates, Enals, Enones
10. Lecture 11: Aldehydes & Ketones: Kinectic Energy, Halogenation, Alkylation, Enamines, Aldol condensation, Carbonyls
11. Lecture 12: Unsaturated Carbonyls, HCN, O & N Nucleophiles, Ether formation, Organometallics, Carboxylic Acids
12. Lecture 13: Graphene, Acidity, Basicity, Hydrolysis, Reactions, Nucleophilic substitution, Synthesis, Anhydrides, Esters
13. Lecture 14: Ester, Lactones, Amides, Penicillins, lactams, Hell-Volhard-Zelinsky Reaction, Reactivity, Alcohols, Amines
14. Lecture 15: Organometallics, acyl chlorides and aldehydes, Friedel-Crafts, Grignard and Hydride reagents
15. Lecture 16: Amide enolates and amidates, Hofmann rearrangement, Alkanenitriles, Alkaloids, Nylon
16. Lecture 17: Ammonium Salts
17. Lecture 18: Chemistry of Substituted Benzenes
18. Lecture 20: Phenol Synthesis
19. Lecture 21: Ester Enolates, Mixed Ketone and the Claisen Condensation, Michael Addition, Robinson Annulation
20. Lecture 22: Stoichiometric reagents, alkanal coupling using thiazolium ion catalyst, aldehyde coupling, Carbohydrates
21. Lecture 23: Formation of Glucose and Fructose, Glucopyranoses, Reactions of Sugars, Esters and Ethers: Protection
22. Lecture 24: Higher Saccharides: Sucrose, Lactose, Cellulose, Starch, Glycogen. Heterocycles
23. Lecture 25: Aromatic Heterocycles, Pyridine: Azabenzene, Amino Acids
24. Lecture 26: Synthesis of Amino Acids, Peptides, Protein, Edman degradation
25. Lecture 27: Synthesis of Polypeptides, Nucleic Acids, Protein Synthesis, Genetechnology, Human Genome

Chemistry 3B, 002: Chemical Structure and Reactivity (Fall 2010)
In this course, Prof. K. Peter Vollhardt gives 25 video lectures on chemical structure and reactivity.

Topics: Conjugation, aromatic chemistry, carbonyl compounds, carbohydrates, amines, carboxylic acids, amino acids, peptides, proteins, and nucleic acid chemistry. Ultraviolet spectroscopy and mass spectrometry will be introduced.