In this National Institutes of Health program, Marc L. Reitman, chief of the molecular biology and gene regulation section of the National Institute of Diabetes & Digestive & Kidney diseases, reviews current information on obesity and related complications. He also describes how a limited amount of fat can contribute to overall health. At least $30 billion is spent treating obesity-related conditions in the United States every year. While researchers suspect genetic and environmental factors may influence obesity, effective treatment options remain limited. Find out what current research may indicate for the future of obesity and diabetes.