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Lecture Description
The overview video for Module 2 of Useful Genetics.
Course Index
- Overview of Module 1
- How different are we?
- Properties of DNA
- Properties of genes
- Why molecular biology is confusing
- Properties of chromosomes
- Life cycles and ploidy
- Comparing DNA sequences
- Genetic and evolutionary relationships of human populations
- Overview of Module 2
- Fidelity of DNA replication
- Why most mutations are harmless
- Types of mutations and their consequences
- Germline and Somatic Mutations
- Mutagens (what should we worry about)
- Mutations, selection and evolvability
- Origins and evolution of new genes and gene families
- Comparing DNA sequences reveals evolutionary history
- Overview of Module 3
- Protein basics
- Catalytic proteins (enzymes)
- Structural, transport and carrier proteins
- Regulatory proteins and RNAs
- Homozygous phenotypes
- Diploids: Heterozygous phenotypes
- All about dominance
- How genes are named
- Gene interaction in biochemical pathways
- Regulatory interactions
- How somatic mutations cause cancer
- Frameworks for predicting the phenotypic effects of mutation
- Overview of Module 4
- Sex chromosomes and sex determination
- Expression of X‐linked genes in females
- Expression of X‐linked genes in males
- Can natural genetic variation explain natural phenotypic variation?
- Most natural variation has very small effects
- Many natural genetic variants affect multiple traits
- Effects of natural genetic variation depend on the environment
- Effects of natural genetic variation depend on chance
- How natural genetic variation affects the risk of cancer
- Integrating new understanding into old concepts
- Overview of Module 5
- DNA fingerprinting
- Analyzing a single gene or gene 'panel'
- SNP-typing the genome, Part 1
- SNP-typing the genome, Part 2
- SNP-typing services
- Exome sequencing
- Haplotypes
- Ancestry
- Ethical and social issues surrounding personal genomics
- Not-so-personal genomics
- Overview of Module 6
- Mitosis
- Sexual life cycles
- Meiosis, the basics
- Following genotypes through meiosis, part 1
- More about meiosis: homolog pairing and crossing-over
- Following genotypes through meiosis (this time with crossovers)
- Mating
- Following alleles through generations
- Relatedness
- Sex chromosomes in meiosis
- Overview of Module 7
- Genetic analysis began with Mendel
- Mendels findings and what we now know
- How to do genetic analysis
- Mendel's genetic analysis
- Detecting sex-linkage, predicting outcomes
- Using crosses to investigate locations of autosomal genes
- Using pedigrees to investigate family inheritance
- Using crosses to investigate gene function
- Genetic analysis: numbers matter
- Overview of Module 8
- Heritability
- GWAS redux
- Inbreeding
- Inbreeding in livestock and pets
- Inbreeding and genetic variation in evolution and conservation
- Hybrids
- Plant Breeding & Transgenics
- Overview of Module 9
- Polyploidy
- Aneuploidy
- Aneuploidy for sex chromosomes
- Chromosomes rearrangements
- Consequences of chromosome rearrangements
- Small changes (structural variation)
- Junk and selfish DNA
- Genome evolution
- Overview of Module 10
- Origin of Life
- Mitochondrial genetics
- Epigenetics
- Mosaics and chimeras
- Fetal DNA
- Genetics of aging
Course Description
This college-level course gives students a thorough understanding of gene function, and enables them to apply this understanding to real-world issues, both personal and societal.
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