Modern spectroscopic tools show not only the constitution, configuration, and conformation of glucose but also how it interconverts between isomeric hemiketal pyranose rings. One of mankind's great accomplishments was determinining its constitution and especially its configuration before such spectroscopy. By 1887 Heinrich Kiliani had established the constitution of glucose as an aldohexose, and with help from Emil Fischer, he developed a method for homologating aldoses. Fisher assembled a great deal of experimental evidence on interconversion of natural and artificial aldoses, and their derivatives, especially their crystalline osazones. In 1892 he used this evidence to prove logically which of eight aldohexose configurations corresponds to glucose and to provide definitive support for van't Hoff's stereochemical theory. In 1991 Cram, Tanner, and Thomas reported the NMR spectrum of antiaromatic cyclobutadiene, which they prepared by photolysis inside a clamshell molecule that they designed and constructed in order to isolate this highly reactive molecule.

1. Mechanism: How Energies and Kinetic Order Influence Reaction Rates
2. Peculiar Rate Laws, Bond Dissociation Energies, and Relative Reactivities
3. Rate and Selectivity in Radical-Chain Reactions
4. Electronegativity, Bond Strength, Electrostatics, and Non-Bonded Interactions
5. Solvation, H-Bonding, and Ionophores
6. Brønsted Acidity and the Generality of Nucleophilic Substitution
7. Nucleophilic Substitution Tools - Stereochemistry, Rate Law, Substrate, Nucleophile, Leaving Group
8. Solvent, Leaving Group, Bridgehead Substitution, and Pentavalent Carbon
9. Pentavalent Carbon? E2, SN1, E1
10. Cation Intermediates - Alkenes: Formation, Addition, and Stability
11. Carbocations and the Mechanism of Electrophilic Addition to Alkenes and Alkynes
12. Nucleophilic Participation During Electrophilic Addition to Alkenes: Halogen, Carbene, and Borane
13. Addition to Form Three-Membered Rings: Carbenoids and Epoxidation
14. Epoxide Opening, Dipolar Cycloaddition, and Ozonolysis
15. Metals and Catalysis in Alkene Oxidation, Hydrogenation, Metathesis, and Polymerization
16. Isoprenoids, Rubber, and Tuning Polymer Properties
17. Alkynes; Conjugation in Allylic Intermediates and Dienes
18. Linear and Cyclic Conjugation Theory; 4n+2 Aromaticity
19. Aromatic Transition States: Cycloaddition and Electrocyclic Reactions
20. Electronic and Vibrational Spectroscopy
21. Functional Groups and Fingerprints in IR Spectroscopy; Precession of Magnetic Nuclei
22. Medical MRI and Chemical NMR
23. Diamagnetic Anisotropy and Spin-Spin Splitting
24. Higher-Order Effects, Dynamics, and the NMR Time Scale
25. C-13 and 2D NMR - Electrophilic Aromatic Substitution
26. Aromatic Substitution in Synthesis: Friedel-Crafts and Moses Gomberg
27. Triphenylmethyl and an Introduction to Carbonyl Chemistry
28. Mechanism and Equilibrium of Carbonyl Reactions
29. Imines and Enamines; Oxidation and Reduction
30. Oxidation States and Mechanisms
31. Periodate Cleavage, Retrosynthesis, and Green Chemistry
32. Measuring Bond Energies: Guest Lecture by Prof. G. Barney Ellison
33. Green Chemistry; Acids and Acid Derivatives
34. Acids and Acid Derivatives
35. Acyl Insertions and a-Reactivity
36. α-Reactivity and Condensation Reactions
37. Proving the Configuration of Glucose and Synthesizing Two Unnatural Products
38. Review: Synthesis of Cortisone

This is a continuation of Freshman Organic Chemistry I (CHEM 125a), the introductory course on current theories of structure and mechanism in organic chemistry for students with excellent preparation in chemistry and physics. This semester treats simple and complex reaction mechanisms, spectroscopy, organic synthesis, and some molecules of nature.