Recorded on April 19, 2012

Index of Topics:

4:10-HCN Addition and Wittig Reaction
7:13-Ketones or Aldehydes and Amines
10:32-Aldimine Formation Example
15:23-Ketimine Formation Example
19:55-Mechanism of Acid-Catalyzed Imine Formation
33:28-Acid-Catalyzed Breakdown of the Hemiaminal
44:33-Answer to Student Question
47:50-Imine Formation
49:49-Reversibility
53:15-Example of Reversibility
55:50-Enanamines
59:04-Nucleophilicity of Amine
1:01:50-Imine Reaction with Base

1. Introduction to Carboxylic Acids.
2. Reactivity of Carbonyl Compounds.
3. Reactions of Organometallic Reagents.
4. Reactions and Protecting Groups.
5. Aldehydes and Ketones: Reactions.
6. Formation of Imines & Enamines from Aldehydes & Ketones.
7. Acid-Catalyzed Formation of Hydrates, Hemiacetals, & Acetals.
8. The Chemistry of the Carboxylic Acid Family.
9. Reactions of Carboxylic Acids, Esters, Amides, & Nitriles.
10. Enols and Enolates.
11. More Reactions of Enols and Enolates.
12. The Aldol Reaction and the Michael Reaction.
13. The Robinson Annulation and the Claisen Reaction.
14. Introduction to Amines: Properties and Synthesis.
15. Hofmann Degradation, Diazotization, & Aryl Diazonium Salts.
16. Introduction to Carbohydrates: Structure and Stereochemistry
17. More Structure, Stereochemistry, & Reactions of Carbohydrates.
18. Amino Acids, Peptides, and Proteins.
19. Organometallic Reactions in Organic Synthesis.

This is the third quarter course in the organic chemistry series. Topics covered include: Fundamental concepts relating to carbon compounds with emphasis on structural theory and the nature of chemical bonding, stereochemistry, reaction mechanisms, and spectroscopic, physical, and chemical properties of the principal classes of carbon compounds.

Organic Chemistry 51C is part of OpenChem. http://ocw.uci.edu/collections/open_chem