Recorded on May 17, 2012

Index of Topics:

1:40-Michael Reaction
4:19-Aldol Reaction
5:54-Aldol Reaction with Dehydration
8:32-The Robinson Annulation
13:13-Reactions Involved in Robinson Annulation
26:15-Robinson Annulation Example
28:11-Retrosynthesis Example
33:55-Synthesizing Examples
39:55-Other Conditions
41:11-Acid-Catalyzed Michael Reaction
43:30-Acid-Catalyzed Aldol Reaction
45:18-Example Problem
50:00-Claisen Reaction
53:21-Claisen Reaction Mechanism
57:59-Synthesis Example
1:04:27-Crossed Claisen Reaction
1:08:46-Retro-Claisen Reaction Mechanism
1:11:04-Dieckmann Reaction
1:17:41-Synthesis Example

1. Introduction to Carboxylic Acids.
2. Reactivity of Carbonyl Compounds.
3. Reactions of Organometallic Reagents.
4. Reactions and Protecting Groups.
5. Aldehydes and Ketones: Reactions.
6. Formation of Imines & Enamines from Aldehydes & Ketones.
7. Acid-Catalyzed Formation of Hydrates, Hemiacetals, & Acetals.
8. The Chemistry of the Carboxylic Acid Family.
9. Reactions of Carboxylic Acids, Esters, Amides, & Nitriles.
10. Enols and Enolates.
11. More Reactions of Enols and Enolates.
12. The Aldol Reaction and the Michael Reaction.
13. The Robinson Annulation and the Claisen Reaction.
14. Introduction to Amines: Properties and Synthesis.
15. Hofmann Degradation, Diazotization, & Aryl Diazonium Salts.
16. Introduction to Carbohydrates: Structure and Stereochemistry
17. More Structure, Stereochemistry, & Reactions of Carbohydrates.
18. Amino Acids, Peptides, and Proteins.
19. Organometallic Reactions in Organic Synthesis.

This is the third quarter course in the organic chemistry series. Topics covered include: Fundamental concepts relating to carbon compounds with emphasis on structural theory and the nature of chemical bonding, stereochemistry, reaction mechanisms, and spectroscopic, physical, and chemical properties of the principal classes of carbon compounds.

Organic Chemistry 51C is part of OpenChem. http://ocw.uci.edu/collections/open_chem